1.political realities are usually enough to plunge us into total despair.
政治现实通常足以我们陷入彻底的绝望。
2.Meanwhile he sits in solitary confinement in Guantanamo, in total despair, contemplating whether he should just commit suicide.
而此时彻底绝望的他正坐在关达那摩与世隔绝的牢房里，思考着是不是该自杀。
3.In total despair, the prisoner believed that no one in the world would trust him any more.
囚犯万念俱灰，心想，这世界上再也不会有人相信他了。